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Updated: May 27, 2026

Characterize Disease-related Mutants of RAF Family Kinases by Using a Set of Practical and Feasible Methods
07:49

Characterize Disease-related Mutants of RAF Family Kinases by Using a Set of Practical and Feasible Methods

Published on: July 17, 2019

RAF阻害剤に対する耐性は,異常にスプライスされたBRAF ((V600E)) の二酸化によって媒介されます

Poulikos I Poulikakos1, Yogindra Persaud, Manickam Janakiraman

  • 1Department of Molecular Pharmacology and Chemistry, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.

Nature
|November 25, 2011
PubMed
まとめ

メラノーマにおけるRAF阻害剤に対する新しい耐性メカニズムには,BRAF (V600E) スプライシングの変種が含まれています. これらの変異は,RASから独立した二分化を促進し,ERK経路の活性化と患者におけるヴェムラフェニブ耐性につながる.

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Employing Digital Droplet PCR to Detect BRAF V600E Mutations in Formalin-fixed Paraffin-embedded Reference Standard Cell Lines10:16

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