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Updated: May 12, 2026

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FBXO11はBCL6の分解を標的とし,拡散型大B細胞リンパ腫では不活性化されます

Shanshan Duan1, Lukas Cermak, Julia K Pagan

  • 1Department of Pathology, NYU Cancer Institute, New York University School of Medicine, New York, New York 10016, USA.

Nature
|November 25, 2011
PubMed
まとめ

FBXO11の不活性化はBCL6の安定化につながり,拡散型大B細胞リンパ腫 (DLBCL) の発症を促進します. FBXO11を復元すると,DLBCL細胞増殖と腫瘍発生性を抑制し,FBXO11を腫瘍抑制剤として識別します.

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