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Updated: May 27, 2026

Cycloheximide Chase Analysis of Protein Degradation in Saccharomyces cerevisiae
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Cycloheximide Chase Analysis of Protein Degradation in Saccharomyces cerevisiae

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破滅への道:エンドプラズマ網膜の分解のためのタンパク質をターゲットにすること

Melanie H Smith1, Hidde L Ploegh, Jonathan S Weissman

  • 1Department of Cellular and Molecular Pharmacology, Graduate Group in Biophysics and Howard Hughes Medical Institute, University of California-San Francisco, CA 94158, USA.

Science (New York, N.Y.)
|November 26, 2011
PubMed
まとめ

エンドプラズマ網膜 (ER) の誤った折りたたまれたタンパク質は,ER関連分解 (ERAD) 経路によって分解されます. ERADの成分は知られているが,誤折りたたまれたタンパク質の特徴と,タンパク質の半減期調節におけるそれらの役割の特定には,さらなる研究が必要である.

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