関連する実験動画

Updated: May 4, 2026

CRISPR-Mediated Reorganization of Chromatin Loop Structure
09:20

CRISPR-Mediated Reorganization of Chromatin Loop Structure

Published on: September 14, 2018

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CRL4DDB2/CSAユビキチンリガゼの構造,ターゲティング,および活性化の分子基礎

Eric S Fischer1, Andrea Scrima, Kerstin Böhm

  • 1Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058 Basel, Switzerland.

Cell
|November 29, 2011
PubMed
まとめ

CRL4 (((DDB2) リガゼはDDB2経由で紫外線で損傷したDNAを認識するが,COP9シグナルゾーム (CSN) によって抑制される. DDB2へのDNA結合は,この抑制を解放し,CRL4リガース活性化の一般的なメカニズムを明らかにします.

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In Vitro Analysis of E3 Ubiquitin Ligase Function06:06

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