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ヒストンH2BのGLCNAcylationは,そのモノウビキチン化を促進する

Ryoji Fujiki1, Waka Hashiba, Hiroki Sekine

  • 1Institute of Molecular and Cellular Biosciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.

Nature
|November 29, 2011
PubMed
まとめ

O-リンクされたN-アセチルグルコサミン (GlcNAc) は,O-GlcNAcトランスファーゼ (OGT) によってS112におけるヒストンH2Bの改変により,H2Bのユビキチン化を促進する. このGlcNAcylationは,グルコースレベルをクロマチンの調節と遺伝子転写と結びつける.

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