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Updated: May 27, 2026

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
10:33

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

Published on: October 26, 2015

サイドチェーン相互作用は,無秩序なペプチドとPDZドメインの間の結合反応で遅れて,協力的に形成されます

S Raza Haq1, Celestine N Chi, Anders Bach

  • 1Department of Medical Biochemistry and Microbiology, Uppsala University, BMC Box 582, SE-75123 Uppsala, Sweden.

Journal of the American Chemical Society
|December 2, 2011
PubMed
まとめ

本質的に無秩序なタンパク質は,弱い初期複合体を形成する. ネイティブの相互作用は結合障壁の後に発達し,結合親和性は主に関連率によって引き起こされるという理論に異議を唱える.

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Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues07:08

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