関連する実験動画

Updated: May 26, 2026

CD Spectroscopy to Study DNA-Protein Interactions
06:48

CD Spectroscopy to Study DNA-Protein Interactions

Published on: February 10, 2022

転写の鍵と鍵: σ-DNA相互作用

Xin Liu1, David A Bushnell, Roger D Kornberg

  • 1Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.

Cell
|December 14, 2011
PubMed
まとめ

RNAポリメラーゼはDNAプロモーターを認識し,相互接続されたメカニズムを通じてRNA合成のためのDNA鎖を分離します. 新しい結晶構造は,プロモーター認識とDNA解の間の驚くべき関連性を明らかにしています.

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Cooperative Binding of Transcription Regulators02:13

Cooperative Binding of Transcription Regulators

Transcriptional regulators bind to specific cis-regulatory sequences in the DNA to regulate gene transcription. These cis-regulatory sequences are very short, usually less than ten nucleotide pairs in length. The short length means that there is a high probability of the exact same sequence randomly occurring throughout the genome.  Since regulators can also bind to groups of similar sequences, this further increases the chances of random binding. Transcriptional regulators form dimers that...
Cooperative Binding of Transcription Regulators02:13

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Transcriptional regulators bind to specific cis-regulatory sequences in the DNA to regulate gene transcription. These cis-regulatory sequences are very short, usually less than ten nucleotide pairs in length. The short length means that there is a high probability of the exact same sequence randomly occurring throughout the genome.  Since regulators can also bind to groups of similar sequences, this further increases the chances of random binding. Transcriptional regulators form dimers that...
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For successful DNA replication, the unwinding of double-stranded DNA must be accompanied by stabilization and protection of the separated single strands of the DNA. This crucial task is performed by single-strand DNA-binding (SSB) proteins. They bind to the DNA in a sequence-independent manner, which means that the nitrogenous bases of the DNA need not be present in a specific order for binding of SSB proteins to it. The binding of SSB proteins straightens single-stranded DNA (ssDNA) and makes...
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Eukaryotic Transcription Inhibitors

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Transcription in Prokaryotes

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