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Updated: May 5, 2026

CRISPR-Mediated Reorganization of Chromatin Loop Structure
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ポリコンブ抑制遺伝子には,再プログラムを開始する許容性増強剤があります

Phillippa C Taberlay1, Theresa K Kelly, Chun-Chi Liu

  • 1Department of Urology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.

Cell
|December 14, 2011
PubMed
まとめ

増強剤は,重要な調節遺伝子を活性化することによって,細胞運命を再プログラムする上で重要な役割を果たします. H3K4me1によって標識されたこれらの増強剤は,転写調節体の結合とクロマチンの変化を促進する核細胞欠乏領域を作り出します.

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