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Updated: May 26, 2026

A Guide to Production, Crystallization, and Structure Determination of Human IKK1/α
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システインメチル化により,NF-κB活性化におけるユビキチン鎖感知が妨げられます

Li Zhang1, Xiaojun Ding, Jixin Cui

  • 1Graduate Program in Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.

Nature
|December 14, 2011
PubMed
まとめ

Enteropathogenic Escherichia coli NleEは,NF-κBシグナル伝達に不可欠なTAB2およびTAB3タンパク質をメチル化することによって,宿主免疫反応を阻害する. このバクテリアエフェクターは,鍵となるウビキチン鎖結合を無効化し,感染中に先天性免疫を乱します.

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