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Imaging the Intracellular Trafficking of APP with Photoactivatable GFP
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GSK-3α/βキナーゼとアミロイドの生産 in vivo

Tomasz Jaworski1, Ilse Dewachter, Benoit Lechat

  • 1Experimental Genetics Group, KU Leuven, Leuven, Belgium.

Nature
|December 14, 2011
PubMed
まとめ

この研究では,アルツハイマー病におけるグリコゲン合成キナーゼ3 (GSK-3) の役割が調査されました. 研究者らは,GSK-3αまたはβが脳内のアミロイド前駆タンパク質 (APP) 処理を直接制御する証拠が見つかりませんでした.

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Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...
Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...