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Updated: May 26, 2026

Immunometabolic Circuits in Infection for Advancing Host Directed Therapies
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均衡性核酸輸送体3の欠乏は,リソソーム機能とマクロファージのホメオスタシスを乱します

Chia-Lin Hsu1, Weiyu Lin, Dhaya Seshasayee

  • 1Immunology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.

Science (New York, N.Y.)
|December 17, 2011
PubMed
まとめ

均衡性ヌクレオシドトランスポーター3 (ENT3) の欠陥は,リゾソームの蓄積と細胞クリアランスの障害を引き起こし,マクロファージ駆動ヒスティオサイトーシスを引き起こす. この研究は,特定のリソソーム貯蔵疾患の背後にある重要なメカニズムを明らかにしています.

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