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関連する概念動画

Immunoglobulin-like Cell Adhesion Molecules01:31

Immunoglobulin-like Cell Adhesion Molecules

Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
Cell Adhesion Molecules - Types and Functions01:20

Cell Adhesion Molecules - Types and Functions

Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
The Integrin family of proteins is primarily  involved in a...
Cell Adhesion Molecules - Types and Functions01:20

Cell Adhesion Molecules - Types and Functions

Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
The Integrin family of proteins is primarily  involved in a...
Anchoring Junctions01:03

Anchoring Junctions

Anchoring junctions are multiprotein complexes that help cells connect to other cells and the extracellular matrix. Anchoring junctions are present on the lateral and basal surfaces of cells, providing strong and flexible connections. Focal adhesions are often formed due to cell interactions with the ECM substrata, which initiate signal transduction via kinase cascades and other mechanisms. Together, they provide stability and tissue integrity. There are three types of anchoring junctions:...
Intracellular Signaling Affects Focal Adhesions01:17

Intracellular Signaling Affects Focal Adhesions

Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
Overview of Cell-Matrix Interactions01:24

Overview of Cell-Matrix Interactions

The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...

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関連する実験動画

Updated: May 26, 2026

Ligand Nano-cluster Arrays in a Supported Lipid Bilayer
10:34

Ligand Nano-cluster Arrays in a Supported Lipid Bilayer

Published on: April 23, 2017

膜に固定されたオリゴヌクレオチドとの化学的にプログラムされた細胞結合.

Nicholas S Selden1, Michael E Todhunter, Noel Y Jee

  • 1Department of Pharmaceutical Chemistry, University of California, San Francisco, 600 16th Street Box 2280, San Francisco, California 94158, USA.

Journal of the American Chemical Society
|December 20, 2011
PubMed
まとめ
この要約は機械生成です。

研究者らは,DNAを用いて細胞粘着を制御する新しい化学的方法を開発した. この技術により,タンパク質にかかわらず,素早く調節可能な細胞結合が可能になり,細胞の行動や薬物の効果を研究する新しい方法が生まれます.

さらに関連する動画

Simple, Affordable, and Modular Patterning of Cells using DNA
08:59

Simple, Affordable, and Modular Patterning of Cells using DNA

Published on: February 24, 2021

Bead Aggregation Assays for the Characterization of Putative Cell Adhesion Molecules
08:15

Bead Aggregation Assays for the Characterization of Putative Cell Adhesion Molecules

Published on: October 17, 2014

関連する実験動画

Last Updated: May 26, 2026

Ligand Nano-cluster Arrays in a Supported Lipid Bilayer
10:34

Ligand Nano-cluster Arrays in a Supported Lipid Bilayer

Published on: April 23, 2017

Simple, Affordable, and Modular Patterning of Cells using DNA
08:59

Simple, Affordable, and Modular Patterning of Cells using DNA

Published on: February 24, 2021

Bead Aggregation Assays for the Characterization of Putative Cell Adhesion Molecules
08:15

Bead Aggregation Assays for the Characterization of Putative Cell Adhesion Molecules

Published on: October 17, 2014

科学分野:

  • バイオケミストリー バイオケミストリー
  • 分子生物学は分子生物学である.
  • マテリアルサイエンス 材料科学

背景:

  • 細胞粘着は組織組織と統合に不可欠です.
  • 現在の方法は,しばしばタンパク質やグリカンに依存し,制御を制限し,複雑性を導入します.
  • 細胞の粘着を精密に化学的に制御する必要性が存在します.

研究 の 目的:

  • DNAオリゴヌクレオチドを用いて細胞粘着を制御するための化学的戦略を開発する.
  • タンパク質とグリカンから独立した細胞相互作用を可能にします.
  • 細胞膜ダイナミクスを研究するためのこの方法の有用性を実証する.

主な方法:

  • フォスフォラミジットから合成された膜に固定された単一鎖DNAオリゴヌクレオチド.
  • 細胞と表面のDNA鎖間の互補的な相互作用を活用した.
  • 化学的に固定された非粘着性のヒト細胞は,被動化されたガラス表面に貼り付けられています.

主要な成果:

  • DNAベースの戦略を使用して,迅速で効率的で調整可能な細胞結合を達成しました.
  • 細胞表面の天然のタンパク質やグリカンから独立して,細胞粘着性が実証されている.
  • 固定された細胞の膜ダイナミクスにおける薬物誘発による変化を成功裏に画像化しました.

結論:

  • 膜に固定されたDNAオリゴヌクレオチドは,細胞粘着を制御するための多用途の化学的アプローチを提供します.
  • この方法は,細胞の不動化とダイナミックな細胞プロセスを研究するための強力なツールを提供します.
  • 反応剤の化学的性質は,単純な合成と広範な適用性を可能にします.