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Visualization of ATP Synthase Dimers in Mitochondria by Electron Cryo-tomography
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無傷のThermus thermophilus H+駆動ATP合成酵素のサブナノメートルの解像度構造

Wilson C Y Lau1, John L Rubinstein

  • 1Molecular Structure and Function Program, The Hospital for Sick Children Research Institute, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada.

Nature
|December 20, 2011
PubMed
まとめ

研究者らは,陽子駆動型ATP合成酵素の構造を明らかにし,イオンフローが細胞のエネルギー生産にどのように力を貸すかを詳細に説明しました. この画期的な発見は,回転性ATPアゼで陽子の運動力を回転に変換するメカニズムを明らかにした.

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V-type pumps are ATP-driven pumps found in the vacuolar membranes of plants, yeast, endosomal and lysosomal membranes of animal cells, plasma membranes of a few specialized eukaryotic cells, and some prokaryotes. They are also known as the V1Vo-ATPase, that couple ATP hydrolysis to transport protons against a concentration gradient.
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