休息時の心拍数における時間的変化と,心不全性疾患による死亡
Javaid Nauman1, Imre Janszky, Lars J Vatten
1K. G. Jebsen Center of Exercise in Medicine, PO Box 8905, Medisinsk Teknisk Forskningssenter, 7491 Trondheim, Norway.
JAMA
|December 22, 2011
まとめ
10年以上にわたる休息時の心拍数 (RHR) の増加は,発血性心疾患 (IHD) による死亡リスクの上昇と関連しています. この研究は,心血管の健康のためにRHRの変化をモニタリングすることの重要性を強調しています.
科学分野:
- 心臓病学 心臓病学
- エピデミオロジー エピデミオロジー
- 公衆衛生は公衆衛生である.
背景:
- 休息時の心拍数 (RHR) は,心血管リスクの既知の予測因子です.
- タイムラルRHRの変化が一般人における心不全性疾患 (IHD) 死亡率に与える影響は不明である.
研究 の 目的:
- RHRの長期的な縦断的な変化とIHDによる死亡リスクとの関連性を調査する.
- RHRの変動と全因死亡率との関係を評価する.
主な方法:
- ノルウェーの29,325人を対象とした前向きなコホート研究で,RHRは約10年の間隔で2回測定されました.
- コックス回帰分析は,RHRの変化に基づいて,IHDと全因死亡率の危険比率を推定するために使用されました.
- 死亡率の追跡調査は,2008年12月31日まで行われました.
主要な成果:
- 10年間のRHRの増加は,IHDによる死亡リスクの有意な増加と関連していました.
- RHRが<70から>85ビート/分に増加した参加者は,IHD死亡のリスクが1.9倍に増加しました.
- RHRの変化とIHDの死亡率との関連は線形ではなく,RHRの減少による死亡率の利益は観察されなかった.
結論:
- 前回の心血管疾患のない個体では,10年以上にわたるRHRの上昇は,IHDの死亡率の上昇リスクと関連しています.
- 時間の経過とともにRHRの増加は,すべての原因による死亡率の増加とも相関していましたが,IHDの死亡率よりも低い程度でした.
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