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Updated: May 26, 2026

Making Conjugation-induced Fluorescent PEGylated Virus-like Particles by Dibromomaleimide-disulfide Chemistry
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Making Conjugation-induced Fluorescent PEGylated Virus-like Particles by Dibromomaleimide-disulfide Chemistry

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ポリマー二ブロモマレイミドは,非常に効率的な二硫化物ブリッジングバイオコンジュガーションおよびペギレーション剤として使用されています

Mathew W Jones1, Rachel A Strickland, Felix F Schumacher

  • 1Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK.

Journal of the American Chemical Society
|December 23, 2011
PubMed
まとめ

ディブロモマレイミドは,二硫化結合に挿入することでペプチドを効率的に結合させ,ペプチドの構造を保ちます. この迅速な方法では,Tris(2-カルボキシエチル) フォスフィン (TCEP) を使用し,複雑な浄化なしでサイト固有のペギレーションとポリマー結合を可能にします.

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