重度のうつ病:新しい臨床,神経生物学,治療の視点
David J Kupfer1, Ellen Frank, Mary L Phillips
1University of Pittsburgh Medical Center, Western Psychiatric Institute and Clinic, PA, USA. Kupferdj@upmc.edu
Lancet (London, England)
|December 23, 2011
まとめ
大うつ病 (MDD) の診断と神経生物学における最近の進歩は,改善された評価と治療の選択を提供します. しかし,完全に満足のいく治療法はまだ入手できず,継続的な研究の必要性を強調しています.
科学分野:
- 精神科医は精神病を患っている.
- 神経科学は神経科学である.
- 薬理学 薬理学とは
背景:
- 大うつ病 (MDD) の診断と治療は,過去5年間で著しい進歩を遂げました.
- 併発性,神経生物学的要因,治療効果は,重点的な分野である.
研究 の 目的:
- MDDの診断,神経生物学,治療における最近の進展をレビューする.
- 評価と治療の選択に関連する遺伝的,分子的,および神経イメージング研究を強調する.
- MDDの現在のおよび新興の治療戦略について議論する.
主な方法:
- 過去5年間に発表された研究の文献レビュー.
- MDDにおける精神病および医学的な併発性に関する研究の分析.
- 遺伝的,分子的,および神経イメージングの発見の検討.
- 心理療法,抗うつ薬,体療法の評価について.
主要な成果:
- 改善されたMDDの評価と管理のための共病性の強調.
- 治療の選択のための神経生物学的マーカーの識別.
- うつ病特有の心理療法と既存の/新しい抗うつ剤の化合物の議論.
- SSRIによる自殺リスクと,妊娠中の抗うつ薬の安全性の検討.
結論:
- MDDの理解と治療において,著しい進展がみられた.
- 現在の治療法は依然として不最適であり,さらなる研究開発が必要である.
- 併発性および神経生物学を考慮した統合的アプローチは,MDDの効果的な管理に不可欠です.
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