癌の免疫療法は年齢によって生まれます
Ira Mellman1, George Coukos, Glenn Dranoff
1Genentech, 1 DNA Way, South San Francisco, California 94080, USA. mellman.ira@gene.com
Nature
|December 24, 2011
まとめ
癌の免疫療法が飛躍的な進歩を遂げました. 抗CTLA4抗体であるイピリムマブは,転移性メラノーマの生存率を大幅に改善し,患者にとって持続的な反応を提供します.
科学分野:
- 免疫学と腫瘍学について
- 癌 免疫療法 免疫療法
背景:
- がんに対する免疫系を活性化することは,長年の目標です.
- 従来の治療法は,転移性メラノーマではしばしば失敗する.
- 最近の臨床試験は,がんの免疫療法に希望を示しています.
研究 の 目的:
- 最近のがん免疫療法試験の成功を強調するために.
- 持続的ながん反応のための活性免疫療法の可能性を議論する.
主な方法:
- 免疫療法剤を評価する臨床試験.
- 患者の生存データの分析.
主要な成果:
- 抗CTLA4抗体であるイピリムマブは,転移性メラノーマの生存率を大幅に増加させた.
- イピリムマブは,従来の治療法が失敗したときに有効性を示しました.
結論:
- イピリムマブが例示するアクティブ免疫療法は,持続的ながん治療の有効な経路を表しています.
- 免疫調節と標的治療の理解における進歩は,免疫療法の役割を支持しています.
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