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Updated: May 26, 2026

Chemical Triphosphorylation of Oligonucleotides
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Chemical Triphosphorylation of Oligonucleotides

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ピロホスファートイオンの放出と,結合されたトリガーループの動きの動態は,RNAポリメラーゼIIにおける閉じた状態から開いた状態に変化する

Lin-Tai Da1, Dong Wang, Xuhui Huang

  • 1Department of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong.

Journal of the American Chemical Society
|December 31, 2011
PubMed
まとめ

RNAポリメラーゼII (pol II) から放出されるピロホスファートイオン (PP(i)) は,転写に極めて重要です. 分子動力学シミュレーションでは,H1085,K752,K619などの特定の残留物が,ホッピングメカニズムを通じてPPの放出を促進することを明らかにしています.

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