腹腔外科手術と長期的な心血管疾患
Lars Sjöström1, Markku Peltonen, Peter Jacobson
1Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. lars.v.sjostrom@medfak.gu.se
JAMA
|January 5, 2012
まとめ
腹腔外科手術は,通常のケアと比較して,肥満の成人における心血管疾患による死亡およびイベントを著しく減少させた. この減量介入は,主要な心血管疾患に対する保護を提供します.
科学分野:
- 心血管の健康についてです.
- 肥満医学 肥満医学とは
- 外科手術のイノベーション
背景:
- 肥満は,心血管疾患の重要な危険因子です.
- 心血管保護のための減量介入を支持する証拠は限られている.
- 減量手術は重度の肥満に対する主要な減量介入である.
研究 の 目的:
- 減量手術と心血管疾患との関連を調査する.
- 心血管疾患による死亡率と罹患率に対する外科的な体重減少の影響を評価する.
- 肥満患者における減量外科手術の心血管上の利点に関する証拠を提供するため.
主な方法:
- スウェーデンの肥満被験者 (SOS) 研究は,前向きな,制御された,ランダム化されていない試験です.
- 2010年,肥満の参加者は減量手術を受けた;2037匹の肥満の対照群は通常のケアを受けた.
- 追跡期間は平均14.7年であり,心血管疾患による死亡,心筋梗塞,脳卒中を分析した.
主要な成果:
- 腹腔外科手術は,心血管疾患による死亡率の減少と関連していた (HR,0.47;P = .002).
- 総合心血管疾患 (心筋梗塞または脳卒中) の発生率は,手術を受けたグループでは低かった (HR, 0.67; P < .001).
- これらの結果は,混同要因を調整した後も依然として重要でした.
結論:
- 減量手術は,肥満の成人の心血管疾患による死亡の減少と関連しています.
- 減量手術を受けた肥満者は,通常のケアを受けている人と比較して,心血管疾患の発生率が低いことを経験します.
- この研究は,減量外科手術の心血管保護効果の有力な証拠を提供します.
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