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Updated: May 26, 2026

Iterative Optimization of DNA Duplexes for Crystallization of SeqA-DNA Complexes
11:42

Iterative Optimization of DNA Duplexes for Crystallization of SeqA-DNA Complexes

Published on: November 1, 2012

TALエフェクタ PthXo1の結晶構造は,そのDNAターゲットに結合しています

Amanda Nga-Sze Mak1, Philip Bradley, Raul A Cernadas

  • 1Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, A3-025 Seattle, WA 98019, USA.

Science (New York, N.Y.)
|January 7, 2012
PubMed
まとめ

トランスクリプションアクティベーターのようなエフェクター (TALEs) は,反復変数ダイレシデュ (RVDs) とのタンデムリピートを使用してDNAを認識します. PthXo1の結晶構造は,これらの繰り返しがDNAを結合する超ヘリックスを形成し,TALE-DNAの認識を明らかにすることを明らかにしています.

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Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens09:53

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