RNA編集は,極性タコのK+チャネルにおける温度適応の基礎となっている

Sandra Garrett¹, Joshua J C Rosenthal

¹Institute of Neurobiology, University of Puerto Rico-Medical Sciences Campus, San Juan 00901, PR.

Science (New York, N.Y.)

|January 7, 2012

まとめ

章魚のイオンチャネルにおけるRNA編集は,環境温度に適応する. 寒さに適応した種は,チャンネルを大きく編集し,機能を変化させるが,熱帯の種はそうせず,環境への反応性を示す.

科学分野:

* 分子生物学 * 分子生物学
* 遺伝学について
* 神経科学は神経科学である.

背景:

* 心理的な生物は極度の寒さに適応する必要があり,遺伝的および分子的なメカニズムが潜在的に関与しています.
*イオンチャネルは細胞機能に不可欠であり,環境適応の候補である.

研究の目的:

*タコのイオンチャネルにおける熱適応の分子基礎を調査する.
* イオンチャネルの機能的多様化におけるRNA編集の役割を調査する.

主な方法:

*南極と熱帯の種からのタコの遅延矯正器K ((+)) チャンネルの遺伝子配列決定.
* 機能的特性を評価するために,Xenopus卵細胞におけるチャネル遺伝子の発現.
*特定の部位でのメッセンジャーRNA (mRNA) 編集の分析.

主要な成果:

* Octopus K(+) チャンネル遺伝子は,南極と熱帯の種間の最小限の配列の相違を示しました.
* 南極と北極のタコのmRNAでは広範なRNA編集が観察されましたが,熱帯の種ではそうではありません.
* 毛穴内のイソルエウシンからバリンに変化する特定の編集部位は,チャンネルゲーティング運動を著しく加速しました.

結論:

*RNA編集,特にアデノシンからイノシンへの編集は,イオンチャネルの機能的多様性を提供します.
*イオンチャネル内のRNA編集レベルは,環境温度に反応し,精神性愛者のための適応機構を示唆しています.
* この研究は,極端な環境への生物の適応における重要な役割を果たすRNA編集を強調しています.

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