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Updated: May 26, 2026

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids
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ランゲルハンズ細胞は,上皮のDNA損傷と状細胞癌を促進します

Badri G Modi1, Jason Neustadter, Elisa Binda

  • 1Department of Dermatology, Yale University School of Medicine, New Haven, CT 06520, USA.

Science (New York, N.Y.)
|January 7, 2012
PubMed
まとめ

ランゲルハンズ細胞 (LCs) は,DMBAのような発がん性ポリアロマティック炭化水素 (PAH) を代謝し,皮膚がんを促進します. LCsの除去は,PAH誘発のDNA損傷と変異からマウスを保護し,これらの免疫細胞が化学的発がんに重要な役割を果たしていることを明らかにします.

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