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Updated: May 26, 2026

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A Murine Model of Group B Streptococcus Vaginal Colonization
Published on: November 16, 2016
3ヶ月未満の乳児のグループB型 estreptococcal疾患: システマティック・レビューとメタ解析
Karen M Edmond1, Christina Kortsalioudaki, Susana Scott
1London School of Hygiene and Tropical Medicine, London, UK. karen.edmond@lshtm.ac.uk
Lancet (London, England)
|January 10, 2012
まとめ
グループB型ストレプトコッカス (GBS) は,世界的に幼児の重大な病気と死亡の原因となっています. GBSの5つの血清タイプを標的としたワクチンは,侵襲的なGBS疾患の症例のほとんどを予防することができます.
科学分野:
- グローバル・ヘルス グローバル・ヘルス
- 感染症 感染症は感染症です.
- 小児科は小児科です.
背景:
- グループB型ストレプトコッカス (GBS) は,世界中で乳児の罹病率と死亡率の主な原因です.
- 産内抗生物質予防は広く使用されていますが,GBS疾患負担の推定値は多くの地域では不足しています.
研究 の 目的:
- 侵入性GBS疾患の現在の世界的な負担を調査する.
- GBS単離体の血清型の分布を決定する.
主な方法:
- Medline,Embase,およびWholisのデータベースで,侵入性GBS疾患 (早期発症および遅発症) に関する研究を検索しました.
- 発生率,死亡率,または血清型を報告した研究;参照リストをレビューし,未発表データについて専門家に連絡した.
- ランダム効果メタアナリシスを利用して,対象となる74の研究のデータをまとめました.
主要な成果:
- 乳児におけるGBSの平均発生率 (0-89日) は,生児1000人当たり0.53であり,症例死亡率は9.6%であった.
- 早期発症のGBSの発生率と死亡率は,遅発症のGBSの2倍でした.
- 血清型IIIが最も一般的であった (48.9%),次にIa (22.9%),V (9.1%),Ib (7.0%),II (6.2%) が続いた.
結論:
- GBSの負担を正確に推定するには,特に低所得国において,より質の高い研究が必要である.
- 血清型Ia,Ib,II,III,Vを標的とした結合ワクチンは,世界のGBS疾患のほとんどを予防することができます.
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