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Updated: May 26, 2026

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コレプレッサーとイノシトールテトラホスファートに結合するHDAC3の構造

Peter J Watson1, Louise Fairall, Guilherme M Santos

  • 1Henry Wellcome Laboratories of Structural Biology, Department of Biochemistry, University of Leicester, Leicester LE1 9HN, UK.

Nature
|January 11, 2012
PubMed
まとめ

ヒストン脱酸化酵素 (HDACs) は,重要ながん標的である. 研究者らは,イノシトールテトラホスファート分子が分子接着剤として作用し,HDAC3と遺伝子調節のための共同抑制剤複合体の形成を可能にすることを発見しました.

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