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マリファナへの曝露と20年以上の肺機能との関連
Mark J Pletcher1, Eric Vittinghoff, Ravi Kalhan
1Department of Epidemiology and Biostatistics, University of California, San Francisco, 185 Berry St, Ste 5700, San Francisco, CA 94107, USA. mpletcher@epi.ucsf.edu
JAMA
|January 12, 2012
まとめ
偶発的なマリファナ使用は肺機能に害を及ぼさなかったが,大量使用は異なった結果を示した. この研究では,マリファナを分析した.
科学分野:
- 肺内医学 肺内医学 肺内医学
- エピデミオロジー エピデミオロジー
- 毒理学 毒理学 毒理学
背景:
- マリファナの煙は,タバコの煙と成分を共有し,肺機能への影響について疑問を投げかけています.
- マリファナの肺への影響に関する既存の研究は限られており,時には矛盾しています.
- 投与量と反応の関係を理解することは,公衆衛生のガイドラインにとって極めて重要です.
研究 の 目的:
- マリファナ曝露 (現在および生涯) と肺機能との関連性を調査する.
- 肺容量に対するマリファナの効果とタバコの煙の効果を比較するために.
- マリファナの使用が呼吸器の健康に線形または非線形の影響を与えるかどうかを判断する.
主な方法:
- 若年成人における冠動脈動脈リスク発達 (CARDIA) 長期研究 (20年) のデータを活用した.
- 5115人の参加者の肺機能測定値 (FEV,FVC) を分析した.
- 混合線形モデリングを採用し,タバコの使用をコントロールとして考慮し,共同年のマリファナ曝露を定量化しました.
主要な成果:
- タバコの使用は,線形的に FEV の減少と関連しており,FVC.
- マリファナの肺機能との関連は非線形であった.
- 低レベルのマリファナ使用は,FEV ((1)) とFVCのわずかな増加を示した;重度の使用は,FVCが上昇したまま,これらの効果の均衡または逆転を示した.
結論:
- 偶発的および低累積マリファナ使用は,肺機能の悪影響と関連していません.
- 大量のマリファナ使用は,肺機能に複雑で非線形的な効果を示しています.
- 大量のマリファナの使用が肺に及ぼす長期的な影響を完全に解明するには,さらなる研究が必要です.
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