ダイアストリック機能不全の進行が正常なエジェクション分数を有する患者の死亡率に与える影響
Wael Aljaroudi1, M Chadi Alraies, Carmel Halley
1Sydell and Arnold Miller Family Heart and Vascular Institute, Robert and Suzanne Tomsich Department of Cardiovascular Medicine, 9500 Euclid Ave/J1-5, Cleveland, OH 44195, USA. aljarow@ccf.org
Circulation
|January 21, 2012
まとめ
正常な左心房放出分数を持つ患者の下痢機能の悪化は,独立して死亡率を予測します. この発見は,心血管の健康におけるダイアストリック機能不全の進行の予後的重要性を強調しています.
科学分野:
- 心臓病学 心臓病学
- エコーカルディオグラフィー エコーカルディオグラフィー
- 予測バイオマーカー
背景:
- ダイアストリック機能不全は,正常な射出分数を持つ患者の死亡率を予測します.
- ディアストリック機能の悪化に関連した予後に関するデータは限られている.
研究 の 目的:
- ダイアストリック機能の悪化が死亡リスクの増加と関連しているかどうかを調査する.
- 発射分子が保存された患者のダイアストリック機能の変化の予後値を分析する.
主な方法:
- 1065人の室外患者 (2005年 - 2009年) のエコーカルジオグラムの遡及的レビュー.
- ダイアストリック機能と左心室のエジェクション分数の変化を時間とともに評価した.
- 生存分析のためにカプラン・マイヤーとコックス回帰を用いた.
主要な成果:
- 72.3%がベースラインのダイアストリック機能不全を示し,16%がフォローアップ時に悪化を示した.
- ダイアストリック機能の悪化とエジェクション分数の低下は,より高い死亡率と関連していました.
- 死亡率に対するリスク比は,ダイアストリック機能の悪化に対して1.78であった (P=0.003).
結論:
- ダイアストリック機能の悪化は,正常なベースラインエジェクション分数を有する患者の死亡率を独立して予測します.
- 静脈機能の進行は,この集団における有意な予後指標である.
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