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関連する概念動画

Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Histone Modification02:32

Histone Modification

The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone deacetylase,...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Regulation of Metabolism01:19

Regulation of Metabolism

Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Histone Modification02:32

Histone Modification

The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone deacetylase,...

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関連する実験動画

Updated: May 10, 2026

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies
14:56

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies

Published on: May 6, 2022

繋がる糸:表遺伝学と代謝

Sayako Katada1, Axel Imhof, Paolo Sassone-Corsi

  • 1Center for Epigenetics and Metabolism, School of Medicine, University of California, Irvine, Irvine, CA 92697, USA.

Cell
|January 24, 2012
PubMed
まとめ
この要約は機械生成です。

ダイエットは子孫の表遺伝学に影響し,ヒストンが代謝を感知することを示唆しています. メタボライトレベルがクロマチンの変形剤を制御する方法を理解することは,代謝状態を安定した遺伝子発現パターンに変換する鍵です.

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Unveiling Histone Proteoforms using 2D-TAU Gel Electrophoresis
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Unveiling Histone Proteoforms using 2D-TAU Gel Electrophoresis

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In Vivo Monitoring of Transcriptional Activity During Metabolic Transition Using a Bioluminescent Reporter in Yeast

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Last Updated: May 10, 2026

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies
14:56

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies

Published on: May 6, 2022

Unveiling Histone Proteoforms using 2D-TAU Gel Electrophoresis
07:20

Unveiling Histone Proteoforms using 2D-TAU Gel Electrophoresis

Published on: October 18, 2024

In Vivo Monitoring of Transcriptional Activity During Metabolic Transition Using a Bioluminescent Reporter in Yeast
06:53

In Vivo Monitoring of Transcriptional Activity During Metabolic Transition Using a Bioluminescent Reporter in Yeast

Published on: February 21, 2025

科学分野:

  • エピジェネティクスと分子生物学
  • メタボリック調節 メタボリック調節
  • 遺伝子発現制御 遺伝子発現制御

背景:

  • 染色体修正酵素は,表遺伝子遺伝を媒介することを提案されています.
  • 食事による影響は,エピジェネティックで子孫に伝染することがあります.
  • ヒストンは代謝センサーとして機能し,代謝と遺伝子発現を結びつけます.

研究 の 目的:

  • エピジェネティック継承におけるクロマチン修正酵素の役割を調査する.
  • ヒストンが代謝センサーとしてどのように作用するかを調査する.
  • メタボリート変動がクロマチンの改変に影響を与えるメカニズムを理解する.

主な方法:

  • ダイエットと表遺伝的変化の関連性を調査する.
  • 代謝状態の指標としてヒストンの改変を分析する.
  • 代謝産物によるクロマチンの変形剤の空間的・時間的制御を研究する.

主要な成果:

  • 証拠によると,食事によって引き起こされる表遺伝的変化は遺伝的であることが示されています.
  • ヒストンは代謝信号を遺伝子発現パターンに変換するようです.
  • メタボリットの変動は,クロマチンの変形剤を動的に調節する.

結論:

  • クロマチンの変形剤は,表遺伝子遺伝において重要な役割を果たします.
  • ヒストンは,代謝状態と遺伝子発現の間の架け橋として機能する.
  • メタボライト主導のクロマチンの調節の正確なメカニズムを明らかにするためにさらなる研究が必要である.