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関連する概念動画

Replicative Cell Senescence02:15

Replicative Cell Senescence

Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds the telomeric...
Replicative Cell Senescence02:15

Replicative Cell Senescence

Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds the telomeric...
Aging01:26

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Methods of Nuclear Reprogramming01:24

Methods of Nuclear Reprogramming

Nuclear reprogramming is a process of transforming one cell type into an unrelated cell type by epigenetic changes that alter the cell’s original gene expression pattern. Such epigenetic changes force cells to express a different set of genes, which play a significant role in inducing transformation into other cell types. Nuclear reprogramming offers applications in reproductive cloning for livestock propagation and regenerative medicine — developing patient-specific cells for injury repair.
Somatic to iPS Cell Reprogramming01:29

Somatic to iPS Cell Reprogramming

Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012 for this...
Introduction to Nuclear Reprogramming01:14

Introduction to Nuclear Reprogramming

Nuclear reprogramming is the process of switching gene expression of one cell type to that of another cell type, usually from a differentiated cell state to an undifferentiated cell state. Differentiation occurs during processes such as development and morphogenesis, tissue regeneration, and malignancy. Cells can also be artificially induced to reprogram their gene expression by techniques such as nuclear transfer, induced pluripotency, and cell fusion. Such techniques have many applications in...

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関連する実験動画

Updated: May 25, 2026

Measuring Single-Cell Aging with an Imaging-based Biomarker of Chromatin and Epigenetic Aging
09:10

Measuring Single-Cell Aging with an Imaging-based Biomarker of Chromatin and Epigenetic Aging

Published on: January 30, 2026

老化,若返り,および表遺伝的再プログラム:老化の時計をリセットする.

Thomas A Rando1, Howard Y Chang

  • 1The Glenn Laboratories for the Biology of Aging, Stanford University School of Medicine, Stanford, CA 94305, USA. rando@stanford.edu

Cell
|January 24, 2012
PubMed
まとめ

老化は生物学的ミステリーですが,新しい研究によると,老化時計は逆転することができます. エピジェネティック・リプログラミングは,高齢化した細胞や組織の若さを理解し,潜在的に回復するための枠組みを提供します.

科学分野:

  • 生物学 生物学 生物学とは
  • 遺伝学 遺伝学とは
  • エピジェネティクス エピジェネティクス

背景:

  • 老化プロセスを駆動する根本的なメカニズムは,依然としてほとんど不明です.
  • 最近の研究によると,老化は柔軟で,潜在的に逆転可能であることが示されています.

研究 の 目的:

  • 生物学的老化の文脈で,エピジェネティック再プログラミングの新興分野を見直す.
  • エピジェネティック状態として若さや衰えを定義することで,老化に関する研究がどのように進めるかを探求する.

主な方法:

  • 老化と若返りに関する最近の研究の文献レビュー.
  • 重要なメカニズムとして表遺伝的再プログラミングに焦点を当てます.

主要な成果:

  • 証拠によると,老化の速度は遺伝的および環境的要因によって影響を受けることが示唆されています.
  • 老化プロセスは逆転可能であり,若さの特徴を回復する可能性があります.

結論:

  • エピジェネティック再プログラミングは,老化を調査するための新しい枠組みを提示します.
  • 青春と老化を表遺伝的状態として見ると,年齢の逆転に関する研究に新しい道が開きます.

さらに関連する動画

Induction and Validation of Cellular Senescence in Primary Human Cells
08:18

Induction and Validation of Cellular Senescence in Primary Human Cells

Published on: June 20, 2018

関連する実験動画

Last Updated: May 25, 2026

Measuring Single-Cell Aging with an Imaging-based Biomarker of Chromatin and Epigenetic Aging
09:10

Measuring Single-Cell Aging with an Imaging-based Biomarker of Chromatin and Epigenetic Aging

Published on: January 30, 2026

Induction and Validation of Cellular Senescence in Primary Human Cells
08:18

Induction and Validation of Cellular Senescence in Primary Human Cells

Published on: June 20, 2018