調整されたシリアスビートには,基礎足を通した基礎体のODF2媒介の極化が必要である
Koshi Kunimoto1, Yuji Yamazaki, Tomoki Nishida
1Laboratory of Biological Science, Graduate School of Frontier Biosciences and Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan.
Cell
|January 24, 2012
まとめ
Odf2タンパク質は,シリアの基礎足の形成に不可欠です. 基礎足の喪失は,調整されたシリアス鼓動を妨害し,呼吸道清掃に影響を与え,マウスの呼吸器の症状を引き起こします.
科学分野:
- 細胞生物学 細胞生物学
- 呼吸器系生物学 呼吸器系生物学について
- 分子生物学は分子生物学である.
背景:
- トラクエのシリアは,粘液の浄化のための鼓動の座標です.
- シリアは基礎体から発生し,基礎足と関連しています.
- Odf2/cenexinは,基礎体とセンターソームに関連したタンパク質です.
研究 の 目的:
- 基礎体の形成と機能におけるOdf2の役割を調査する.
- 毛細管の調整と呼吸道クリアランスにおける基礎足の重要性を決定する.
主な方法:
- 発生したOdf2 ((ΔEx6,7/ΔEx6,7) は,ODf2エクソン6と7が破壊されたマウスで発生した.
- ミュータントマウスにおける状の構造,鼓動の調整,および呼吸道フェノタイプを分析した.
- 頂点微小管の網羅の極化組織を調べました.
主要な成果:
- Odf2(ΔEx6,7/ΔEx6,7) のマウスはシリアを形成したが,不協調な鼓動と呼吸器の問題を示した.
- 残留 Odf2 発現はシリオゲネシスを支持したが,基礎体には基礎足が欠けていた.
- 基礎足の喪失は,平面細胞の極性に影響を与えることなく,アピカルマイクロチューブルの格子組織を混乱させた.
結論:
- Odf2は基礎足の形成に不可欠です.
- 基礎足は,基礎体の極化調整に不可欠である.
- 調整されたシリアスビートと効果的な呼吸道クリアランスには,適切な基礎体の整列が必要である.
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