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Updated: May 25, 2026

Measuring G-protein-coupled Receptor Signaling via Radio-labeled GTP Binding
10:13

Measuring G-protein-coupled Receptor Signaling via Radio-labeled GTP Binding

Published on: June 9, 2017

19F-NMRによって特徴づけられるβ2-アドレナリン受容体におけるバイアスシグナル伝達経路

Jeffrey J Liu1, Reto Horst, Vsevolod Katritch

  • 1Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.

Science (New York, N.Y.)
|January 24, 2012
PubMed
まとめ

Gタンパク質結合受容体 (GPCRs) に対するリガンド結合は,受容体構造をシフトさせます. アゴニストはヘリックスVI経由でGタンパク質シグナル伝達を活性化し,バイアスリガンドはヘリックスVII経由でGタンパク質シグナル伝達を活性化し,β-アレスティンシグナル伝達に影響を及ぼします.

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