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Updated: May 25, 2026

Screening Traditional Chinese Medicine Compounds for Inhibiting UCHL3 Activity Based on Molecular Docking and Deubiquitinating Enzyme Probe Technology
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Screening Traditional Chinese Medicine Compounds for Inhibiting UCHL3 Activity Based on Molecular Docking and Deubiquitinating Enzyme Probe Technology

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タンパク質の化学合成によって活性化されたデウビキキチナゼを標的とする

Shimrit Ohayon1, Liat Spasser, Amir Aharoni

  • 1Department of Chemistry, Ben-Gurion University of the Negev, Beer Sheva 84105, Israel.

Journal of the American Chemical Society
|January 28, 2012
PubMed
まとめ

研究者らは,デウビキチナゼ (DUB) 阻害剤をスクリーニングするために新しいFRETベースの測定法を開発しました. このアッセイでは,UCH-L3の強力な阻害剤を特定し,DUB関連疾患の薬剤発見を支援しました.

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The Proteasome01:13

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Regulated Protein Degradation02:58

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