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関連する概念動画

Cell Adhesion Molecules - Types and Functions01:20

Cell Adhesion Molecules - Types and Functions

Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
The Integrin family of proteins is primarily  involved in a...
Cell Adhesion Molecules - Types and Functions01:20

Cell Adhesion Molecules - Types and Functions

Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
The Integrin family of proteins is primarily  involved in a...
Immunoglobulin-like Cell Adhesion Molecules01:31

Immunoglobulin-like Cell Adhesion Molecules

Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
Cell Adhesion in Plants01:14

Cell Adhesion in Plants

Plants have rigid cell walls that are made up of cell wall polysaccharides that mediate cell-cell adhesion. The primary cell walls of plants consist of two independent and interacting polysaccharide networks: a pectin matrix that embeds the second network comprising cellulose and hemicelluloses.
Pectins are complex heteropolymers mainly composed of negatively-charged α-D-glucopyranosyl uronic acid and some neutral glycosyl residues such as α-L-rhamnopyranose, α-L-arabinofuranose, and...
Selectins01:25

Selectins

Cell adhesion is  an essential aspect of multicellularity. While stable cell interactions usually occur between cells of the same type, transient cell interactions occur between cells of different tissue types, such as between neutrophils and endothelial cells. Selectins are one class of cell adhesion molecules (CAMs) that bind carbohydrate ligands to form transient cell adhesion. They are rod-like proteins with a long extracellular part of variable length ending with the lectin domain, which...
Overview of Cell-Matrix Interactions01:24

Overview of Cell-Matrix Interactions

The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...

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関連する実験動画

Updated: May 25, 2026

Assay of Adhesion Under Shear Stress for the Study of T Lymphocyte-Adhesion Molecule Interactions
07:40

Assay of Adhesion Under Shear Stress for the Study of T Lymphocyte-Adhesion Molecule Interactions

Published on: June 29, 2016

弱い炭水化物と炭水化物の相互作用によって媒介される細胞粘着のためのモデルシステム.

Bärbel Lorenz1, Luis Álvarez de Cienfuegos, Marieelen Oelkers

  • 1Institute of Physical Chemistry, University of Göttingen, Tammannstrasse 6, 37077 Göttingen, Germany.

Journal of the American Chemical Society
|February 3, 2012
PubMed
まとめ

海洋スポンジの炭水化物は,カルシウム依存の相互作用を通じて細胞間の結合を媒介する. コロイド探査顕微鏡では,これらの多価炭水化物-炭水化物結合のダイナミックな強さとエネルギー環境が明らかになりました.

さらに関連する動画

Bead Aggregation Assays for the Characterization of Putative Cell Adhesion Molecules
08:15

Bead Aggregation Assays for the Characterization of Putative Cell Adhesion Molecules

Published on: October 17, 2014

Adhesion Frequency Assay for In Situ Kinetics Analysis of Cross-Junctional Molecular Interactions at the Cell-Cell Interface
13:22

Adhesion Frequency Assay for In Situ Kinetics Analysis of Cross-Junctional Molecular Interactions at the Cell-Cell Interface

Published on: November 2, 2011

関連する実験動画

Last Updated: May 25, 2026

Assay of Adhesion Under Shear Stress for the Study of T Lymphocyte-Adhesion Molecule Interactions
07:40

Assay of Adhesion Under Shear Stress for the Study of T Lymphocyte-Adhesion Molecule Interactions

Published on: June 29, 2016

Bead Aggregation Assays for the Characterization of Putative Cell Adhesion Molecules
08:15

Bead Aggregation Assays for the Characterization of Putative Cell Adhesion Molecules

Published on: October 17, 2014

Adhesion Frequency Assay for In Situ Kinetics Analysis of Cross-Junctional Molecular Interactions at the Cell-Cell Interface
13:22

Adhesion Frequency Assay for In Situ Kinetics Analysis of Cross-Junctional Molecular Interactions at the Cell-Cell Interface

Published on: November 2, 2011

科学分野:

  • バイオフィジックス 生物物理学
  • マリン・バイオロジー マリン・バイオロジー
  • 炭水化物化学 炭水化物の化学

背景:

  • 細胞-細胞結合は,多細胞生物にとって極めて重要です.
  • スポンジのような海洋生物は,粘着のためにユニークな分子相互作用を利用します.
  • 炭水化物と炭水化物の相互作用を理解することで,生物学的粘着機構の洞察が得られます.

研究 の 目的:

  • Microciona proliferaの膜に固定されたエピトープの多価炭水化物-炭水化物相互作用を調査する.
  • 異なる条件下でホモメア自己結合の動的強さを定量化する.
  • エネルギー景観をモデル化し,これらの相互作用への結合参加を図る.

主な方法:

  • コロイド探査顕微鏡を用いて,相互作用を検知した.
  • 硫酸塩および非硫酸塩の硫酸塩と非硫酸塩のインシット結合を膜で覆われた表面にします.
  • ダイナミック・フォースの測定は,カルシウムイオン濃度と負荷率の関数として行われました.
  • エネルギー景観を分析するために,決定論モデルが適用されました.

主要な成果:

  • この研究では,カルシウムに依存する多価炭水化物と炭水化物の相互作用を特徴づけました.
  • ホモメア自己結合のダイナミック強さを測定した.
  • エネルギー環境と参加債券の数は,決定的モデルを使用して推定されました.

結論:

  • 多価炭水化物-炭水化物相互作用は,海洋生物の細胞-細胞結合において重要な役割を果たします.
  • カルシウムイオンは,これらの相互作用の重要な調節因子です.
  • この発見は,スポンジ細胞の粘着を制御する生体力学的力の定量的な理解を提供します.