結核に対する先天的な免疫:薬剤でバランスを取れるバランス行為
Ajit Lalvani1, Marcel A Behr, Saranya Sridhar
1Tuberculosis Research Unit, National Heart and Lung Institute, Imperial College London, Norfolk Place, London W2 1PG, UK. a.lalvani@imperial.ac.uk
Cell
|February 7, 2012
まとめ
炎症媒介体腫瘍死滅因子α (TNFα) の阻害と過剰生産は,結核 (TB) の発症と治療に影響する. エイコサノイドバランスの遺伝的制御は,個別化された結核治療への道を開きます.
科学分野:
- 免疫学 免疫学とは
- 遺伝学 遺伝学とは
- 感染症 感染症は感染症です.
背景:
- 結核 (TB) の病原化は,炎症媒介体である腫瘍死滅因子α (TNFα) によって影響を受けます.
- 不十分なTNFαレベルと過剰なTNFαレベルは,TBにおける疾患進行と治療応答に影響します.
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