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Updated: May 25, 2026

Assessment of Mitochondrial Functions and Cell Viability in Renal Cells Overexpressing Protein Kinase C Isozymes
15:43

Assessment of Mitochondrial Functions and Cell Viability in Renal Cells Overexpressing Protein Kinase C Isozymes

Published on: January 7, 2013

PKCεは,核内のATF2の腫瘍性機能を促進し,ミトコンドリアにおけるそのアポプトティック機能を阻害する

Eric Lau1, Harriet Kluger, Tal Varsano

  • 1Signal Transduction Program, Sanford-Burnham Medical Research Institute, La Jolla, CA 92037, USA.

Cell
|February 7, 2012
PubMed
まとめ

転写因子ATF2は,ミトコンドリアに局所化することによって,皮膚がんにおける腫瘍抑制剤として作用する. しかし,メラノーマのPKCε濃度の高さは,この機能を阻害し,がんの進行を促進します.

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