性別二型行動のモジュラー遺伝子制御
Xiaohong Xu1, Jennifer K Coats, Cindy F Yang
1Department of Anatomy, University of California, San Francisco, San Francisco, CA 94158, USA.
Cell
|February 7, 2012
まとめ
性ホルモンは脳内の特定の遺伝子を調節し,攻撃性や交尾などの性特有の行動を制御します. これらの遺伝子を破壊すると,マウスの標的型行動欠陥が生じます.
科学分野:
- 神経科学は神経科学である.
- エンドクリノロジー エンドクリノロジー
- 行動遺伝学 行動遺伝学
背景:
- 性ホルモン (エストロゲン,テストステロン) は,性的に二形的な行動に不可欠です.
- これらの行動のためにホルモンを神経回路と結びつける分子機構は,十分に理解されていません.
研究 の 目的:
- 脳内のホルモン調節遺伝子を特定する.
- 性別特有の行動におけるこれらの遺伝子の役割を決定する.
主な方法:
- 成人マウスの下体と桃体の遺伝子発現パターンを分析した.
- 標的遺伝子の乱れが行動に与える影響を調査した.
主要な成果:
- 性ホルモンによって調節される多数の性二型遺伝子発現パターンを特定した.
- 4つの特定の遺伝子 (Brs3,Cckar,Irs4,Sytl4) を破壊すると,男性の性行動,攻撃性,母性行動,または女性の性行動の正確な欠陥が生じます.
結論:
- 性ホルモンは,性的二形性の行動の特定の構成要素の基礎となる異なる遺伝プログラムを制御する.
- これらの発見は,複雑な行動のための分離可能な遺伝的基盤を明らかにします.
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