Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Inflammatory Response01:28

Inflammatory Response

An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

<i>SPP1</i><sup>hi</sup> macrophages in fibrin niches promote hyperplastic tissue remodeling in rheumatoid arthritis synovium.

Science translational medicine·2026
Same author

ArchVelo: archetypal velocity modeling for single-cell multi-omic trajectories.

Nature communications·2026
Same author

Metadomain and metaloop genome interactions in mammalian T cells.

Cell reports·2026
Same author

Editorial: A new era in the treatment of food allergy.

Frontiers in immunology·2026
Same author

Spontaneous somatic Pten loss contributes to functional heterogeneity of T cells.

Scientific reports·2026
Same author

Opposing functions of distinct regulatory T cell subsets in colorectal cancer.

Immunity·2025

関連する実験動画

Updated: May 25, 2026

Mouse Na&#239;ve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets
07:12

Mouse Naïve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets

Published on: April 16, 2015

エクストラティミカルに生成された調節性T細胞は,粘膜のTH2炎症を制御する.

Steven Z Josefowicz1, Rachel E Niec, Hye Young Kim

  • 1Howard Hughes Medical Institute and Immunology Program, Sloan Kettering Institute, New York, New York 10021, USA.

Nature
|February 10, 2012
PubMed
まとめ

誘発性調節性T (Treg) 細胞は,胸腺由来ではないが,粘膜部位におけるアレルギー性炎症を予防し,腸内微生物群のバランスを維持するために重要である. それらの欠乏は,喘息のようなアレルギー状態につながる.

さらに関連する動画

Determination of Regulatory T Cell Subsets in Murine Thymus, Pancreatic Draining Lymph Node and Spleen Using Flow Cytometry
08:06

Determination of Regulatory T Cell Subsets in Murine Thymus, Pancreatic Draining Lymph Node and Spleen Using Flow Cytometry

Published on: February 27, 2019

Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice
07:17

Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice

Published on: June 22, 2016

関連する実験動画

Last Updated: May 25, 2026

Mouse Na&#239;ve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets
07:12

Mouse Naïve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets

Published on: April 16, 2015

Determination of Regulatory T Cell Subsets in Murine Thymus, Pancreatic Draining Lymph Node and Spleen Using Flow Cytometry
08:06

Determination of Regulatory T Cell Subsets in Murine Thymus, Pancreatic Draining Lymph Node and Spleen Using Flow Cytometry

Published on: February 27, 2019

Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice
07:17

Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice

Published on: June 22, 2016

科学分野:

  • 免疫学 免疫学とは
  • 微生物学 微生物学とは

背景:

  • 粘膜界面は,アレルギーや炎症を引き起こすことなく病原体防御のためのプロおよび抗炎症反応のバランスを要求します.
  • timo (tTreg) や periphery (iTreg) から発生する T (Treg) 細胞は,免疫ホメオスタシスと自己免疫の予防に不可欠です.

研究 の 目的:

  • 粘膜表面の免疫バランスの維持におけるチムス由来 (tTreg) と誘導 (iTreg) 調節性T細胞の異なる役割を調査する.
  • iTreg細胞がアレルギー性炎症を予防し,腸内微生物群の組成を維持するために不可欠であるかどうかを判断する.

主な方法:

  • マウスにおける誘発的調節性T (iTreg) 細胞の微分化の選択的阻害.
  • 自己免疫病理の評価,Tヘルパー細胞応答 (T(H) 1,T(H) 17,T(H) 2および粘膜炎.
  • iTreg欠乏マウスにおける腸内微生物コミュニティの組成の分析.

主要な成果:

  • iTreg細胞が欠けていたマウスは,全身的自己免疫機能を発達させず,T (H) 1 / T (H) 17反応を悪化させなかった.
  • iTreg細胞の欠乏は,胃腸道と肺における重要なT(H) 2型アレルギー性炎症を引き起こした.
  • iTreg細胞の欠如は,腸内微生物群の組成を変化させた.

結論:

  • 甲状腺に由来するTreg細胞は,全身的自己免疫を制御するのに十分である.
  • エクストラティミック iTreg細胞は,粘膜のアレルギー性炎症を抑制し,腸内微生物群を調節する上で重要で独特な役割を果たします.
  • iTreg細胞の機能を理解することは,アレルギー性疾患と腸内不活性症に対処する鍵です.