妊娠中の婦人科がんについて
Philippe Morice1, Catherine Uzan, Sebastien Gouy
1Department of Gynecologic Surgery, Institut Gustave Roussy, Villejuif, France. morice@igr.fr
Lancet (London, England)
|February 14, 2012
まとめ
妊娠中に子宮頸がんと卵巣がんを診断するには,腫瘍のステージと患者要因を慎重に考慮する必要があります. 管理戦略は,がんの種類,ステージ,妊娠3ヶ月によって異なりますが,母と胎児の健康を優先します.
科学分野:
- 婦人科腫瘍学 婦人科腫瘍学
- 妊産婦・胎児医学について
- 腫瘍学 腫瘍学
背景:
- 子宮頸がんと卵巣がんは,妊娠中に診断される最も一般的な婦人科悪性腫瘍です.
- 管理決定は複雑で,がん治療と妊娠継続のバランスをとります.
研究 の 目的:
- 妊娠中の妊婦における子宮頸がんおよび卵巣がんの診断および管理の検討をレビューする.
- 妊娠期と患者の好みを考慮して,初期段階および進行した疾患に対するアプローチの概要を述べる.
主な方法:
- 妊娠中の婦人科がんの管理のための現在の文献と臨床ガイドラインのレビュー.
- ステージを決定するためのMRIや腹腔鏡リンパ解剖のような診断ツールの議論.
- 手術やネオアジュヴァント化学療法を含む治療オプションのケース・バイ・ケース分析.
主要な成果:
- 初期段階の子宮頸がんの管理には,腫瘍の大きさ,結節の段階化,妊娠3ヶ月,保守的なアプローチが可能です.
- 局所的に進行した子宮頸がんの管理は,腫瘍の特徴,妊娠段階,患者の希望に基づいて議論の余地があり,個別化されています.
- 卵巣がんの管理は,組織学,分化,結節状態,ステージ,三ヶ月,および進行または高リスクの症例に考慮されるネオアジュバント化学療法に依存します.
結論:
- 妊娠中の子宮頸がんと卵巣がんの管理には,個別化された多分野アプローチが不可欠です.
- 治療戦略は,特定のがん,妊娠年齢,患者の生殖欲求に合わせなければならない.
- 腫瘍学的結果と胎児の健康状態のバランスをとることは,これらの複雑なケースでは極めて重要です.
関連する概念動画
Disorders of the Female Reproductive System
The female reproductive system can be affected by several disorders, including Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), endometriosis, and various forms of cancer. PMS and PMDD are cyclical conditions that cause physical and emotional distress, with symptoms that include edema, mood swings, and food cravings. PMDD is a more severe form of PMS characterized by increased symptom severity that peaks during the luteal phase and tends to improve or resolve shortly after...
Teratogenicity
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
Oogenesis
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
Cancer Prevention
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
Ovarian Cycle
The menstrual cycle includes a critical component known as the ovarian cycle, which undergoes two main phases each month—the follicular phase and the luteal phase. The follicular phase is variable and averaging around 14 days. Ovulation, triggered by a surge in luteinizing hormone (LH), marks the transition between the two phases. The second phase, the luteal phase, is relatively consistent, lasting approximately 14 days, and is marked by the activity of the corpus luteum. While a cycle length...
Gonadal and Placental Hormones
The gonads, namely the testes in males and the ovaries in females, are pivotal in producing gonadal hormones that orchestrate the intricate processes of sexual development and reproduction.
In males, testosterone is the primary gonadal androgen. It plays a central role in the maturation of male reproductive organs — the penis and testes. Additionally, testosterone is instrumental in the development of secondary sexual characteristics — a deep voice as well as facial and pubic hair growth — and...
In males, testosterone is the primary gonadal androgen. It plays a central role in the maturation of male reproductive organs — the penis and testes. Additionally, testosterone is instrumental in the development of secondary sexual characteristics — a deep voice as well as facial and pubic hair growth — and...

