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Regulation of Expression Occurs at Multiple Steps02:24

Regulation of Expression Occurs at Multiple Steps

Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
Regulation of Expression Occurs at Multiple Steps02:24

Regulation of Expression Occurs at Multiple Steps

Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
Regulation of Expression at Multiple Steps01:23

Regulation of Expression at Multiple Steps

The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the addition of a...
Transcriptional Regulation: Riboswitches01:23

Transcriptional Regulation: Riboswitches

Riboswitches are RNA elements that regulate gene expression by altering their secondary structures in response to specific effector molecules. These elements, located in the leader regions of certain mRNAs, act as transcriptional regulators by toggling between alternative conformations to control downstream gene expression. Riboswitch-mediated regulation is a precise mechanism for modulating biosynthetic pathways, as exemplified by the riboflavin biosynthesis pathway in Bacillus...
Translational Regulation01:29

Translational Regulation

Translational regulation in prokaryotes ensures efficient protein synthesis by controlling ribosome access to mRNA. This regulation is mediated by secondary RNA structures, including translational riboswitches, RNA thermometers, and small RNAs (sRNAs), which respond to intracellular and environmental signals to modulate gene expression.Translational RiboswitchesRiboswitches in the leader region of mRNAs can regulate translation by altering the accessibility of the Shine-Dalgarno (SD) sequence,...
Chromatin Structure Regulates pre-mRNA Processing02:41

Chromatin Structure Regulates pre-mRNA Processing

In eukaryotic cells, nascent mRNA transcripts need to undergo many post-transcriptional modifications to reach the cell cytoplasm and translate into functional proteins. For a long time, transcription and pre-mRNA processing were considered two independent events that occur sequentially in the cell. However, it has now been well established that transcription and pre-mRNA processing are two simultaneous processes that are precisely regulated inside the cell.
The chromatin structure, especially...

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Real-time Analysis of Transcription Factor Binding, Transcription, Translation, and Turnover to Display Global Events During Cellular Activation
12:54

Real-time Analysis of Transcription Factor Binding, Transcription, Translation, and Turnover to Display Global Events During Cellular Activation

Published on: March 7, 2018

RNAダイナミクスによる機能的複雑性と規制.

Elizabeth A Dethoff1, Jeetender Chugh, Anthony M Mustoe

  • 1Department of Chemistry and Biophysics, The University of Michigan, 930 North University Avenue, Ann Arbor, Michigan 48109-1055, USA.

Nature
|February 17, 2012
PubMed
まとめ
この要約は機械生成です。

RNAの構成の変化は,遺伝的調節と生命過程を駆動する. その柔軟で頑丈なダイナミクスは,細胞機能と複雑な生物学的経路の鍵です.

さらに関連する動画

Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins
11:34

Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins

Published on: August 9, 2019

関連する実験動画

Last Updated: May 24, 2026

Real-time Analysis of Transcription Factor Binding, Transcription, Translation, and Turnover to Display Global Events During Cellular Activation
12:54

Real-time Analysis of Transcription Factor Binding, Transcription, Translation, and Turnover to Display Global Events During Cellular Activation

Published on: March 7, 2018

Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins
11:34

Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins

Published on: August 9, 2019

科学分野:

  • 分子生物学は分子生物学である.
  • 遺伝学 遺伝学とは
  • バイオケミストリー バイオケミストリー

背景:

  • RNAの構成の変化は,遺伝的調節に不可欠である.
  • RNAは柔軟性を発揮しますが,特定の塩基配列と堆積相互作用を通じて堅牢なダイナミクスを維持します.
  • 細胞プロセスは,複雑な生産的な経路でRNAのダイナミックな振る舞いを利用します.

研究 の 目的:

  • 細胞プロセスにおけるRNAダイナミクスの役割を調査する.
  • RNAの構造的柔軟性が生物学的複雑性にどのように寄与するかを理解する.
  • 遺伝子回路と生化学経路にRNAダイナミクスの統合を調査する.

主な方法:

  • RNAの構成の変化の分析.
  • RNAベースペアリングとスタッキングの相互作用の調査.
  • 細胞経路へのRNA統合の研究.

主要な成果:

  • RNAのダイナミクスは,遺伝的調節と生命の基本的なプロセスにとって極めて重要です.
  • RNAの構造的柔軟性は,好ましい相互作用によって制約され,強固なダイナミクスにつながります.
  • 細胞メカニズムは,機能的経路のためのRNAダイナミクスを効果的に活用します.

結論:

  • RNAのダイナミクスは,細胞のプロセスにおいて,一般的で根本的な役割を果たします.
  • RNAのダイナミクスの汎用性は,多様な遺伝回路への統合をサポートします.
  • RNAのダイナミクスを理解することは,生物学的複雑性を解読する鍵です.