Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Protein Kinases and Phosphatases02:54

Protein Kinases and Phosphatases

15.2K
Proteins undergo chemical modifications that trigger changes in the charge, structure, and conformation of the proteins. Phosphorylation, acetylation, glycosylation, nitrosylation, ubiquitination, lipidation, methylation, and proteolysis are various protein modifications that regulate protein activity. Such modifications are usually enzyme-driven.
Protein kinases
Many proteins in the cell are regulated by phosphorylation, the addition of a phosphate group. A family of enzymes called kinases...
15.2K
Regulated Protein Degradation02:58

Regulated Protein Degradation

8.9K
It is vital to regulate the activity of enzymatic as well as non-enzymatic proteins inside the cell. This can be achieved either through creating a balance between their rate of synthesis and degradation or regulating the intrinsic activity of the protein. Both these regulation mechanisms play an essential role in the normal functioning of cells.
Protein degradation plays two important roles in the cells. It helps to protect cells from misfolded or damaged proteins before they lead to a...
8.9K
Covalently Linked Protein Regulators02:04

Covalently Linked Protein Regulators

9.6K
Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein....
9.6K
Co-activators and Co-repressors02:04

Co-activators and Co-repressors

8.7K
Gene transcription is regulated by the synergistic action of several proteins that form a complex at a gene regulatory site. This is observed in eukaryotes, where the regulation of gene expression is a complex process. Regulatory proteins in eukaryotes can broadly be classified into two types – regulators that bind directly to specific DNA sequences and co-regulators that associate with regulatory proteins but cannot directly bind to the DNA. These co-regulators are further divided into...
8.7K
Activation Energy01:26

Activation Energy

86.7K
Activation energy is the minimum amount of energy necessary for a chemical reaction to move forward. The higher the activation energy, the slower the rate of the reaction. However, adding heat to the reaction will increase the rate, since it causes molecules to move faster and increase the likelihood that molecules will collide. The collision and breaking of bonds represents the uphill phase of a reaction and generates the transition state. The transition state is an unstable high-energy state...
86.7K
Activation and Inactivation of G Proteins01:22

Activation and Inactivation of G Proteins

11.5K
Heterotrimeric G proteins are guanine nucleotide-binding proteins. As the name suggests, heterotrimeric G proteins are composed of three subunits: alpha, beta, and gamma. They remain GDP-bound or GTP-bound inside the cells and switch between inactive/active states. The Gα subunit possesses the nucleotide-binding pocket that binds guanine nucleotides and switches between GDP or GTP-bound states. In contrast, the Gꞵ and Gγ subunits are always bound together with high...
11.5K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Social Determinants of Health and Impact on Cochlear Implant Performance.

Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·2026
Same author

Validation of an Adaptive Sinonasal Outcome Test.

JAMA otolaryngology-- head & neck surgery·2026
Same author

Concordance Between an Adaptive Sino-Nasal Outcome Test and Imaging Results in Chronic Rhinosinusitis.

JAMA otolaryngology-- head & neck surgery·2026
Same author

Hearing Aid Efficacy-Timely Trial Finds Professional Guidance Trumps Costly Tech.

JAMA otolaryngology-- head & neck surgery·2026
Same author

JAMA Otolaryngology-Head & Neck Surgery-The Year in Review, 2025.

JAMA otolaryngology-- head & neck surgery·2026
Same author

Opioid Dependency After Craniomaxillofacial Trauma Surgery.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery·2026

関連する実験動画

Updated: Feb 6, 2026

Protein Modifications: Protein Kinases and Phosphatases
02:54

Protein Modifications: Protein Kinases and Phosphatases

15.2K

急性鼻炎に対するアモキシチリン:ランダム化制御試験

Jane M Garbutt1, Christina Banister, Edward Spitznagel

  • 1Division of General Medical Sciences, Washington University School of Medicine, Campus Box 8005, 660 S Euclid Ave, St Louis, MO 63110, USA. jgarbutt@dom.wustl.edu

JAMA
|February 17, 2012
PubMed
まとめ

アモキシシリンは,プラセボと比較して,3日目までに急性鼻炎の症状を有意に改善しませんでした. 7日目には症状の改善が見られたが,全体的な結果は類似しており,日常的な抗生物質の使用に疑問を呈している.

科学分野:

  • クリニカル・メディシン 臨床医学
  • 感染症 感染症は感染症です.
  • 薬理学 薬理学とは

背景:

  • 急性鼻炎 (ARS) に対する抗生物質の使用は,その有効性を支持する証拠が限られているにもかかわらず,一般的です.
  • 症状治療に対する抗生物質の漸進的な利点を理解することは,臨床ガイドラインにとって極めて重要です.

研究 の 目的:

  • 急性鼻炎と診断された成人におけるアモキシチリンとプラセボの追加効果を評価する.
  • アモキシチリンがARS患者における生活の質と症状解消に与える影響を評価する.

主な方法:

  • 166人の臨床診断された急性鼻炎の成人を対象としたランダム化プラセボ対照試験です.
  • 参加者は,アモキシチリンまたはプラセボの10日コースを受け,必要に応じて症状治療と併用しました.
  • 生活の質 (シノナス・アウトカム・テスト-16) と症状の改善を含むアウトカムは,複数の時間点で評価されました.

主要な成果:

  • アモキシチリンとプラセボ群のシナノサールアウトカムテスト-16のスコアでは,3日目や10日目には有意な差異はありませんでした.
  • 症状報告の統計的に有意な改善が観察され,7日目のアモキシチリンに好意を示した (P = .02).
  • 再発,再発,または有害事象を含む他の二次的なアウトカムにおいて,有意な違いは見つかりませんでした.

さらに関連する動画

Regulated and Targeted Protein Degradation
02:58

Regulated and Targeted Protein Degradation

8.9K
Covalently Linked Protein Regulators and Post-translational Modification
02:04

Covalently Linked Protein Regulators and Post-translational Modification

9.6K

関連する実験動画

Last Updated: Feb 6, 2026

Protein Modifications: Protein Kinases and Phosphatases
02:54

Protein Modifications: Protein Kinases and Phosphatases

15.2K
Regulated and Targeted Protein Degradation
02:58

Regulated and Targeted Protein Degradation

8.9K
Covalently Linked Protein Regulators and Post-translational Modification
02:04

Covalently Linked Protein Regulators and Post-translational Modification

9.6K

結論:

  • アモキシシリンの10日間の投与は,第3日までに急性鼻炎の症状を軽減する点でプラセボよりも有意な効果を示さなかった.
  • この発見は,急性鼻炎に対する日常的な抗生物質の処方が正当化されない可能性を示唆し,抗生物質の賢明な使用の必要性を強調しています.