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Updated: May 13, 2026

Dissection of Adult Mouse Utricle and Adenovirus-mediated Supporting-cell Infection
11:13

Dissection of Adult Mouse Utricle and Adenovirus-mediated Supporting-cell Infection

Published on: March 28, 2012

ミトコンドリアのストレスは,E2F1のアポプトシス信号を誘発し,失聴を引き起こします

Nuno Raimundo1, Lei Song, Timothy E Shutt

  • 1Department of Pathology, Yale University School of Medicine, New Haven, CT 06520, USA.

Cell
|February 21, 2012
PubMed
まとめ

遺伝性失聴を引き起こすA1555G変異は,ミトコンドリア機能障害,活性酸素種 (ROS) 増加,アポトーシスにつながる. この研究は,ミトコンドリアのストレスと聴覚障害をマウスモデルで結びつけるメカニズムを明らかにしています.

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