微生物誘発のGTPase極性回路におけるダイナミックハブとしてのF-アクチンの特定

Robert C Orchard1, Mark Kittisopikul, Steven J Altschuler

  • 1Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

Cell
|February 21, 2012
PubMed
まとめ

バクテリアの病原体は,F-actinと相互作用するグアニン-ヌクレオチド交換因子 (GEF) を使用して細胞の極性を乗っ取ります. この相互作用はCdc42 GTPaseの偏分を駆動し,哺乳類と細菌の細胞の偏分に関する保存されたメカニズムを明らかにします.

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