関連する実験動画

Updated: May 24, 2026

Primary Orthotopic Glioma Xenografts Recapitulate Infiltrative Growth and Isocitrate Dehydrogenase I Mutation
09:43

Primary Orthotopic Glioma Xenografts Recapitulate Infiltrative Growth and Isocitrate Dehydrogenase I Mutation

Published on: January 14, 2014

IDH1変異は,グリオマハイパーメチレーターのフェノタイプを確立するのに十分です

Sevin Turcan1, Daniel Rohle, Anuj Goenka

  • 1Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.

Nature
|February 21, 2012
PubMed
まとめ

アイソチラート脱水素酵素1 (IDH1) 変異は,メチロームとトランスクリプトームを変化させ,膠原腫におけるCpG島メチレーターフェノタイプ (CIMP) を駆動する. この発見は,グリオマCIMPの分子基礎と,がんの発症と患者の生存に与える影響を明らかにしています.

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Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections

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