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Updated: May 24, 2026

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IDH変異はヒストンの脱甲基化を阻害し,細胞の分化を阻害する

Chao Lu1, Patrick S Ward, Gurpreet S Kapoor

  • 1Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.

Nature
|February 21, 2012
PubMed
まとめ

変異したイソシトラート脱水素酶 (IDH) 酵素は,2-ヒドロキシグルタレート (2HG) を生成し,ヒストンの脱甲基化を阻害することによって細胞分化を阻害する. この発見は,膠原腫のようなIDH変異がんを理解するための意味を持つ.

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