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関連する概念動画

Master Transcription Regulators02:23

Master Transcription Regulators

Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
MAPK Signaling Cascades01:07

MAPK Signaling Cascades

Mitogen-activated protein kinase, or MAPK pathway, activates three sequential kinases to regulate cellular responses such as proliferation, differentiation, survival, and apoptosis. The canonical MAPK pathway starts with a mitogen or growth factor binding to an RTK. The activated RTKs stimulate Ras, which recruits Raf or MAP3 Kinase (MAPKKK), the first kinase of the MAPK signaling cascade. Raf further phosphorylates and activates MEK or MAP2 Kinases (MAPKK), which in turn phosphorylates MAP...
General Transcription Factors01:30

General Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
Transcription Factors02:16

Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
Transcription Factors02:16

Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
Combinatorial Gene Control02:33

Combinatorial Gene Control

Combinatorial gene control is the synergistic action of several transcriptional factors to regulate the expression of a single gene. The absence of one or more of these factors may lead to a significant difference in the level of gene expression or repression.
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...

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関連する実験動画

Updated: May 24, 2026

Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development
09:32

Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development

Published on: June 15, 2017

転写因子c-Mafは,タッチ受容体の発達と機能を制御する.

Hagen Wende1, Stefan G Lechner, Cyril Cheret

  • 1Developmental Biology, Max Delbrück Center (MDC) for Molecular Medicine, Berlin, Germany.

Science (New York, N.Y.)
|February 21, 2012
PubMed
まとめ
この要約は機械生成です。

転写因子c-Mafは,触覚感覚に不可欠である. その変異はメカニカル受容体の発達と機能を妨げ,マウスとヒトの高周波振動検出に影響します.

さらに関連する動画

HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries
10:10

HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries

Published on: March 31, 2019

Using Facial Electromyography to Assess Facial Muscle Reactions to Experienced and Observed Affective Touch in Humans
04:27

Using Facial Electromyography to Assess Facial Muscle Reactions to Experienced and Observed Affective Touch in Humans

Published on: March 15, 2019

関連する実験動画

Last Updated: May 24, 2026

Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development
09:32

Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development

Published on: June 15, 2017

HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries
10:10

HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries

Published on: March 31, 2019

Using Facial Electromyography to Assess Facial Muscle Reactions to Experienced and Observed Affective Touch in Humans
04:27

Using Facial Electromyography to Assess Facial Muscle Reactions to Experienced and Observed Affective Touch in Humans

Published on: March 15, 2019

科学分野:

  • 神経科学は神経科学である.
  • 分子生物学は分子生物学である.
  • 遺伝学 遺伝学とは

背景:

  • 触覚は,機械的刺激を検知する機械感受性ニューロンを含む.
  • 限られた分子データは,機械受容体の発達,多様性,および機能の理解を妨げています.

研究 の 目的:

  • 機械感覚機能における転写因子c-Mafの役割を調査する.
  • 機械受容体の発達と多様性における主要な分子プレーヤーを特定する.

主な方法:

  • 機械受容体の発達と機能を研究するために,c-Maf変異したマウスの分析.
  • パチニアンの体球形質と高周波振動に対する感受性の評価.
  • c-MAF遺伝子変異を有するヒトの検査.

主要な成果:

  • c-Mafは,マウスとヒトの機械感覚機能に不可欠です.
  • パチニアン体球を含む,迅速に適応するメカニカレセプターの発達と機能は,c-Maf変異マウスで障害があります.
  • パチニアン体球はc-MAF変異のマウスでは縮しており,これはc-MAF変異のヒトにおける高周波振動に対する感度低下と相関しています.

結論:

  • 転写因子c-Mafは,メカニカル受容体の発達と機能の重要な調節因子である.
  • c-Mafは,メカニカル受容体とその関連末端器官の発達と機能を規定しています.
  • この発見は,触覚感覚の多様性と機能の基礎についての分子洞察を提供します.