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Updated: May 24, 2026

A High-throughput-compatible FRET-based Platform for Identification and Characterization of Botulinum Neurotoxin Light Chain Modulators
10:30

A High-throughput-compatible FRET-based Platform for Identification and Characterization of Botulinum Neurotoxin Light Chain Modulators

Published on: December 27, 2013

ボトリヌム神経毒は,相互に繋がった複合体の中でNTNHAによって遮断されています

Shenyan Gu1, Sophie Rumpel, Jie Zhou

  • 1Center for Neuroscience, Aging and Stem Cell Research, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.

Science (New York, N.Y.)
|February 25, 2012
PubMed
まとめ

クラストリディアの非毒性非ヘマグルチニン (NTNHA) タンパク質は,ボツリヌス神経毒素 (BoNTs) を胃酸から遮断する. この構造的および生化学的研究は,NTNHAがBoNTsを分解から保護し,潜在的な新しい治療法を可能にする方法を明らかにしています.

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