Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Hydrogen Bonds00:26

Hydrogen Bonds

Hydrogen bonds are weak attractions between atoms that have formed other chemical bonds. One of these atoms is electronegative, like oxygen, and has a partial negative charge. The other is a hydrogen atom that has bonded with another electronegative atom and has a partial positive charge.
Hydrogen Bonds Control the World!
Because hydrogen has very weak electronegativity when it binds with a strongly electronegative atom, such as oxygen or nitrogen, electrons in the bond are unequally shared.
Hydrogen Bonds01:04

Hydrogen Bonds

A hydrogen bond is formed when a weakly positive hydrogen atom already bonded to one electronegative atom (for example, the oxygen in the water molecule) is attracted to another electronegative atom from another polar molecule, such as water (H2O), hydrogen fluoride (HF), or ammonia (NH3). The huge electronegativity difference between the H atom (2.1) and the atom to which it is bonded (4.0 for an F atom, 3.5 for an O atom, or 3.0 for an N atom), combined with the very small size of an H atom...
DNA Base Pairing02:27

DNA Base Pairing

Erwin Chargaff’s rules on DNA equivalence paved the way for the discovery of base pairing in DNA. Chargaff’s rules state that in a double-stranded DNA molecule,
DNA Base Pairing02:27

DNA Base Pairing

Erwin Chargaff’s rules on DNA equivalence paved the way for the discovery of base pairing in DNA. Chargaff’s rules state that in a double-stranded DNA molecule,
The DNA Helix01:16

The DNA Helix

Overview
The DNA Helix01:07

The DNA Helix

Deoxyribonucleic acid, or DNA, is the genetic material responsible for passing traits from generation to generation in all organisms and most viruses. DNA is composed of two strands of nucleotides that wind around each other to form a spring-like structure called a double helix. However, the double helix is not perfectly symmetrical. Instead, there are regularly occurring grooves in the structure. The major groove occurs where the sugar-phosphate backbones are relatively far apart. This space...

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

The Sigma Ring and Other Distinctive Features of Surface Potentials of Group 1 Systems.

The journal of physical chemistry. A·2026
Same author

A Borane Sandwich Analogue of Ferrocene.

Angewandte Chemie (International ed. in English)·2026
Same author

Ultrasound imaging features of cervical lymph nodes with melanoma metastasis compared with benign cervical nodes.

Melanoma research·2026
Same author

HSR26-231: Diagnostic Performance of the Bexa™ Breast Exam for Detection of Breast Masses: A Prospective Single-Center Study.

Journal of the National Comprehensive Cancer Network : JNCCN·2026
Same author

On Covalent N<sub>2</sub>H<sub>6</sub>: A High-Energy, Non-Lewis, Local Minimum That May (Not) Exist.

The journal of physical chemistry. A·2026
Same author

HSR26-231: Diagnostic Performance of the Bexa™ Breast Exam for Detection of Breast Masses: A Prospective Single-Center Study.

Journal of the National Comprehensive Cancer Network : JNCCN·2026

関連する実験動画

Updated: May 24, 2026

From Molecules to Materials: Engineering New Ionic Liquid Crystals Through Halogen Bonding
06:44

From Molecules to Materials: Engineering New Ionic Liquid Crystals Through Halogen Bonding

Published on: March 24, 2018

DNA塩基対におけるハロゲン結合は,

Anna J Parker1, John Stewart, Kelling J Donald

  • 1Department of Chemistry, Gottwald Center for the Sciences, University of Richmond, Richmond, Virginia 23173, United States.

Journal of the American Chemical Society
|February 28, 2012
PubMed
まとめ

ハロゲン結合は,人工DNA塩基対を設計するための新しいアプローチを提供します. ブロム代用核酸化物は,天然の水素結合のペアと比べて安定した構造を示しています.

科学分野:

  • バイオケミストリー バイオケミストリー
  • 化学生物学 化学生物学とは
  • 分子生物学は分子生物学である.

背景:

  • ハロゲン結合 (R-X··Y) は,水素結合に類似しています.
  • 人工タンパク質やニュクレオチドの設計に潜在的応用がある.

研究 の 目的:

  • ハロゲン結合DNA塩基対を改変された核酸で探求する.
  • これらのハロゲン系システムの構造と安定性を,天然の塩基対と比較する.

主な方法:

  • ハロゲン化されたグアニン,サイトシン,アデニン,チミン核酸化物の計算分析.
  • エネルギー安定性と構造コプラナリティの比較.

主要な成果:

  • 安定したコプラナー構造は,ほとんどのハロゲン塩基対で特定されました.
  • ハロゲン酸ペアの安定性は,水素結合類の2 kcal mol (−1) の範囲であった.
  • ブロミン (Br) は,ハロゲン (Cl, Br, I) の中で極化性とステリック適合性の最良のバランスを示した.
  • dA:dTとdG:dCのペアでハロゲン結合に水素結合の単一の置換により,最も安定した構造が得られました.

結論:

さらに関連する動画

Analyzing and Building Nucleic Acid Structures with 3DNA
16:24

Analyzing and Building Nucleic Acid Structures with 3DNA

Published on: April 26, 2013

Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes
05:37

Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes

Published on: April 4, 2025

関連する実験動画

Last Updated: May 24, 2026

From Molecules to Materials: Engineering New Ionic Liquid Crystals Through Halogen Bonding
06:44

From Molecules to Materials: Engineering New Ionic Liquid Crystals Through Halogen Bonding

Published on: March 24, 2018

Analyzing and Building Nucleic Acid Structures with 3DNA
16:24

Analyzing and Building Nucleic Acid Structures with 3DNA

Published on: April 26, 2013

Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes
05:37

Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes

Published on: April 4, 2025

  • ハロゲン結合は,安定した人工DNA塩基対を作成するために効果的に使用することができます.
  • ブロムは,その特性により,このような用途に最も有望なハロゲンです.
  • これらの発見は,新しい核酸構造の合理的な設計を支持します.