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Updated: Mar 13, 2026

Differentiated Mouse Adipocytes in Primary Culture: A Model of Insulin Resistance
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インスリン抵抗性のメカニズム:共通点と欠けているリンク

Varman T Samuel1, Gerald I Shulman

  • 1Department of Medicine, Yale University School of Medicine, New Haven, CT 06510, USA. varman.samuel@yale.edu

Cell
|March 6, 2012
PubMed
まとめ

インスリン抵抗性には,子宮外脂質の蓄積,展開されたタンパク質応答,免疫応答を含む複雑な代謝経路が含まれています. これらの要因は収束し,肝臓と筋肉における脂質代謝物を促進し,インスリンシグナル伝達を損なう.

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