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Updated: May 12, 2026

Identifying DNA Mutations in Purified Hematopoietic Stem/Progenitor Cells
11:06

Identifying DNA Mutations in Purified Hematopoietic Stem/Progenitor Cells

Published on: February 24, 2014

差異化チェックポイントは,DNA損傷に対する反応として,血液形成幹細胞の自己再生を制限する

Jianwei Wang1, Qian Sun, Yohei Morita

  • 1Institute of Molecular Medicine and Max-Planck-Research Department of Stem Cell Aging, University of Ulm, Ulm, Germany.

Cell
|March 6, 2012
PubMed
まとめ

DNAの損傷は,幹細胞の自己再生を制限するチェックポイントを誘発する. 研究者らは,この過程の鍵として,ATFのような基本的なルシンのジッパー転写因子 (BATF) を特定し,血液生成性幹細胞 (HSC) に影響し,潜在的に老化を引き起こす.

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Directed Differentiation of Primitive and Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells14:37

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