スラグとSox9は協力して乳がん幹細胞の状態を決定する

Wenjun Guo¹, Zuzana Keckesova, Joana Liu Donaher

¹Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.

Cell

|March 6, 2012

まとめ

2つの転写因子,スラグとSox9は,協力して乳がん幹細胞 (MaSC) の状態を調節する. 彼らの共同発現は,微分化された細胞をマスク細胞に変換し,乳がん幹細胞の特性を促進します.

科学分野:

幹細胞生物学幹細胞生物学とは
分子腫瘍学は分子腫瘍学である.
遺伝子調節遺伝子調節

背景:

転写因子 (TFs) は幹細胞状態をオーケストラ化しますが,成人幹細胞のマスターレギュレータは不明のままです.
これらの調節体を理解することは,幹細胞研究とがん生物学にとって極めて重要です.

研究の目的:

乳がん幹細胞 (MaSC) の状態を制御する重要な転写因子を特定し,特徴づけること.
これらのTFが正常なマスク細胞機能と乳がん幹細胞の両方で果たす役割を調査する.

主な方法:

主要乳腺上皮細胞における機能的測定法で,MASCの活動を評価する.
転写因子の過剰発現 Slug and Sox9. 転写因子の過剰発現 Slug and Sox9. 転写因子の過剰発現 Slug and Sox9. 転写因子の過剰発現 Slug and Sox 9. 転写因子の過剰発現 Slug and Sox 9.
乳腺の復元能力の分析.
人間の乳がん細胞系と患者データに関する調査.

主要な成果:

スラグとSox9は,MASC州の協同規制機関として特定されました.
SlugまたはSox9の抑制により,MASCの活性が低下した.
Slug と Sox9 の共発は,分化細胞を復元可能性のある MaSC に変換した.
スラグとSox9は,ヒトの乳がん細胞における腫瘍発生および転移の播種能力を促進する.

結論:

SlugとSox9は,正常な乳がん幹細胞の必須で協力的な調節体である.
これらのTFは,がん幹細胞の形成を促し,患者の生存率の低下と関連しています.
これは,正常な幹細胞とがん幹細胞の間の保存された規制メカニズムを強調しています.

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