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神経変性脳における認知機能の表遺伝的阻害である

Johannes Gräff1, Damien Rei, Ji-Song Guan

  • 1Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

Nature
|March 6, 2012
PubMed
まとめ

神経退行性疾患における認知障害は,遺伝子転写の表遺伝的阻害によって引き起こされます. ヒストン脱酸化酵素2 (HDAC2) によって媒介されるこの阻害は逆転し,記憶機能を回復させることができます.

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